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Bosses is an all-encompassing word that is often used to describe any overpowered single enemies who must be killed to progress in game, and cannot be avoided, but most of the time Act Bosses are meant by bosses. Unique Monsters and Super Uniques are also often included. 

Boss Fight is usually set in a specific location, with limited space to kite them. Often it will be very hard, if not impossible, to use a Town Portal, so preparation is advised. In Diablo III, every Boss fight takes place in an isolated chamber, and once it has started, there is no escape: the combat will not end until either side prevails. No mercy, no escape. Death or glory. Even to start a Boss Fight, all players in a group must click the "Yes" button. However, Rift Guardian bosses are spawned in usual locations, and it is possible (nobody said "easy") to escape the battle with them.

In addition to Act Bosses, the following enemies are included into Boss category:

Bosses are either highly resistant or immune to Crowd Control effects, and in the first two games, also had significant resistances to damage.

Overall, boss fights are focused on player skill rather than raw damage per second and damage control, so players need to put all their effort into fight (unless, of course, they are way too overpowered for that boss and difficulty).

All bosses in Diablo II count as Super Unique Monsters, and all bosses in Diablo I and Diablo III are Unique Monsters, indicated by the color of their names.

In Diablo III, many bosses have an Enrage Timer.

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