Cain is a family name borne by several people throughout the history, most notably two members of the Horadrim order.
- Aderes Cain
- Amelia Cain
- Deckard Cain
- Jered Cain (ancient ancestor)
- Jered Cain (Deckard Cain's son)
In addition, two crafted sets in Diablo III are named after either of the characters listed:
One of the Kanai's Cube recipes is named Hope of Cain.