Destruction is the rune word 'VexLoBerJahKo' for polearms or swords in Diablo II: Lord of Destruction.

Destruction has a kaleidoscope of various spell procs and can be very eye-pleasing to use, but in terms of practical benefit it is rather outclassed, especially given the amount of rare runes required to create it.

23% Chance To Cast Level 12 Volcano On Striking
5% Chance To Cast Level 23 Molten Boulder On Striking
100% Chance To Cast level 45 Meteor When You Die
15% Chance To Cast Level 22 Nova On Attack
+350% Enhanced Damage
Ignore Target's Defense
Adds 100-180 Magic Damage
7% Mana Stolen Per Hit
20% Chance Of Crushing Blow
20% Deadly Strike
Prevent Monster Heal
+10 To Dexterity

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