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She is operating a larger Soul Crucible than Kasadya, and after killing her, player must destroy the device manually. Initially, Drygha is shielded from harm, and only becomes vulnerable when all four corpse piles are destroyed. Upon killing her, Myriam Jahzia is found soon afterwards.
In combat, she has Vortex, Fast and Teleporter affixes, and attacks with multiple Reapers, which are summoned both by herself and by the crucible. If players feel overwhelmed, she can be kited to the back of the row and killed with relative ease.