This rune word might seem odd at first, as it has no +% damage modifier - but in actuality, the pure damage component acts largely as if it was added to weapon damage directly. However, this does not show on the character screen, so while your damage might look very low while you wield Grief, it might in fact be extremely high in comparison to what is seen (it is not uncommon for a character to have over 1000% added damage total from equipment and auras).
Furthermore, as the main damage source does not rely on weapon damage, you can make Grief in a very fast low damage weapon such as a Phase Blade to great effect.
This Rune Word only works for Ladder characters.
35% Chance To Cast Level 15 Venom On Striking
+30-40% Increased Attack Speed
Ignore Target's Defense
-25% Target Defense
+(1.875 per character level) 1.875-185.625% Damage To Demons (Based on Character Level)
Adds 5-30 Fire Damage
-20-25% To Enemy Poison Resist
20% Deadly Strike
Prevent Monster Heal
+2 To Mana After Each Kill
+10-15 Life After Each Kill