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Azmodan's consort, Cydaea, guards the Heart while his commanders are fighting in the field. It is very vulnerable, and without a shield to protect it, the heart can be crushed easily. The Nephalem must destroy it to reach The Core of Arreat and kill Azmodan.
Upon entering the central room in the Heart of the Damned, Cydaea confronts the player(s). The player(s) needs to weaken Cydaea in order to dispel the shield surrounding the Heart, which allows the player(s) to destroy it.