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Keys are needed to open locked chests in Diablo II, unless you are an Assassin. They can be purchased from NPCs in town in any act, or found outside of the towns. All keys are the same. They can be stacked up to 12 in an inventory square. Any size stack will simply be listed as "Key" on the ground, in the same way as Arrows or Bolts.
Cost 1 (Buy): 40 Gold
Cost 12 (Buy): 480 Gold
Cost 1 (Sell): 22 Gold
Cost 12 (Sell): 264 Gold