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It can start spawning on items at Item Level 35, but will not be able to spawn on all items until level 41. Some items also are not able to acquire full effect.
It can start spawning on charms at Item Level 1, but will not be able to spawn on all items with full effect until level 19.
+5-10 To Life (Small)
+6-15 To Life (Large)
+5-20 To Life (Grand)