Orb may refer to:
- Sorceress Orbs, a type of weapon that can only be used by a Sorceress
- Ghostly Orb, a type of Monster Spawner
- Health Globes and Power Globes, drop from monsters to restore health or apply Nephalem Glory buffs (used to be called Orbs)
- Progress orbs drop and increase progression in Nephalem Rifts and Greater Rifts
- Sources, a Wizard-only offhand item type.
- Life and Mana/other primary resources are displayed in orbs in the game UI
- Other class resources include Fury, Spirit, Wrath, Arcane Power and Hatred and Discipline