Radament's Sphere is probably best off in the hands of a physical fighter, due to its added Poison damage. With 80 poison damage over four seconds, Radament's Sphere causes a large amount of damage to build up over a relatively short time, compared to other poison enchanted items.
However, Radament's Sphere can easily be included in an equipment build to build up Poison Resist to almost maximum: in combination with equipment such as Venom Ward and Venom Grip, a character can easily raise their Poison Resist to very high levels even in Hell Difficulty.
Still, other than its added poison damage, Radament's Sphere has little other bonuses. Although it has a chance of casting a low level Poison Nova and charges of Poison Explosion, neither are very high level and aren't very effective at damaging enemies.
Required Level: 50
Required Strength: 110
Chance to Block:
Paladin Smite Damage: 12 To 16
+160-200% Enhanced Defense
+20% Increased Chance to Block
+20% Faster Block Rate
5% Chance To Cast Level 5 Poison Nova When Struck
Level 6 Poison Explosion (40 Charges)
Poison Resist +75%
+80 Poison Damage Over 4 Seconds