Skull Splitter has fairly low damage and its chance of Open Wounds is quite small, so it is rarely useful past early game, but it does have certain advantages.
Ironically, spell casters may find Skull Splitter useful, since it gives a bonus to Mana regeneration. Combined with a Sorceress' Warmth, for example, Skull Splitter can help early game casters keep their Mana on the go.
One-Hand Damage: (11-14) To (17-22)
Required Level: 21
Required Strength: 49
Required Dexterity: 33
Axe Class – Fast Attack Speed
+60-100% Enhanced Damage
Adds 1-(12-15) Lightning Damage
+50-100 To Attack Rating
15% Chance Of Open Wounds
Hit Blinds Target +2
Regenerate Mana 20%
(Only spawns in Patch 1.09 or later)